Objective: To explore the indication of hysterectomy on the pregnancy complicating hepatitis gravis．Methods: Sixty two cases of hepatitis gravis patients during pregnancy from 2003 to 2009 were retrospectively analyzed．These patients were grouped according to the criteria prothrobin activity(PTA)≤30% or >30%, serum total bilirubin (TBIL) <342 μmol/L or ≥342 μmol/L, white blood cell count(WBC)<20×109/L or ≥20×109/L, or the occurrence of bilirubin separation．In each group, clinical cure rate were compared using fisher’s exact test between hysterectomy and not-hysterectomy patients． Results: When PTA≤30% or WBC≥20×109/L, the clinical cure rate exist significant different between hysterectomy group and not-hysterectomy group(P<0．05). No statistical difference between hysterectomy group and not-hysterectomy group were found in the other groups(P>0.05)．Conclusion: When PTA≤30% and(or) WBC≥20×109/L，hysterectomy in the pregnancy complicating hepatitis gravis should be considered.
