Objective To investigate the clinical characteristics of 15 adult patients with myelin oligodendrocyte glycoprotein （MOG） immunoglobulin-G （IgG）-associated encephalomyelitis （MOG-EM）. Methods The clinical symptoms, MRI features, laboratory examination, clinical prognosis and follow-up of 15 MOG-EM patients were retrospectively analyzed. Results Among 15 patients, 7 cases were male and 8 female. The average age of onset was （39.0±14.7） years. The most common clinical symptoms were visual impairment（7/15）, followed by limb numbness and paralysis （5/15）. Partial patients presented with relevant symptoms of the brainstem and cerebellum （dysarthria, double vision and unstable walking） or relevant signs of acute disseminated encephalomyelitis, such as consciousness disorder, seizure and memory loss, etc. MRI results detected abnormal lesions in 13 cases （13/15） including 8 cases of cortical/subcortical white matter involvement （8/13） and 4 cases of pontile involvement （4/13）. The thalamus, cerebellum and corpus callosum were also involved. Nine patients received MRI of the whole spinal cord. Among them, 3 cases presented with abnormal lesions, all of which were involved with the cervical spinal cord and 1 case of thoracic spinal cord （1/3）. All 15 patients were tested positive for serum MOG-IgG. Among 11 cases receiving detection of MOG-IgG in the cerebrospinal fluid, 5 cases were positive for MOG-IgG. Eight （8/15） patients recurred. Ten patients received repeated detection of serum MOG-IgG. Among them,5 cases turned negative and 4 of them did not recur. The remaining 5 cases remained positive and recurred. All patients were treated with methylprednisolone and Ig. One patient was supplemented with mycophenolate mofetil. Favorable clinical prognosis was obtained. Conclusions Adult patients with MOG-EM are primarily manifested with optic neuritis, which is involved with cerebral cortex, subcortical white matter and pons. Relatively favorable clinical prognosis can be obtained. The cliical recurrence rate is relatively high. Patients persistently positive for serum MOG-IgG are likely to recur.