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基于鼻腔分泌物细胞因子谱的变应性鼻炎疗效客观评估体系构建：一项范围综述

Developing an objective evaluation system based on cytokine profile in nasal secretions for allergic rhinitis treatment outcomes: a scoping review

    摘要
  • 摘要:
    目的  分析不同的方法治疗前后AR患者鼻腔分泌物细胞因子变化的特点，为建立基于客观指标的临床疗效评估体系提供依据，为后续相关研究和相关政策的制定提供借鉴。
    方法  根据范围综述的方法，在PubMed、Web of Science、中国知网期刊全文数据库（CNKI）和万方数字化期刊全文数据库中，检索从2015年7月1日至2025年7月1日关于鼻腔分泌物细胞因子检测与分析的研究报告。
    结果  共纳入118篇文献，结果显示，Th2型炎症相关细胞因子在多项研究中均呈现治疗后下降的趋势，与此相反，Th1型细胞因子在治疗后普遍上升。
    结论  本研究发现通过检测鼻腔分泌物中Th1及Th2相关细胞因子可作为客观疗效评价标准用于后续相关研究中。

     

    Abstract:
    Objective  To analyze the characteristics of cytokine profile changes in nasal secretions of allergic rhinitis (AR)patients receiving different treatments, with the aim of informing an objective, biomarker-based system for clinical efficacy assessment and guiding future research and policy development.
    Methods To explore objective evaluation indicators, this study conducted a comprehensive search of the studies related to cytokine detection and analysis of in nasal secretions in databases such as PubMed, Web of Science, CNKI and Wanfang Data, covering the period from July 1, 2015 to July 1, 2025.
    Results  118 studies met the inclusion criteria. Across multiple investigations, the levels of Th2-related cytokines consistently decreased after treatment, whereas those of Th1-related cytokines generally increased.
    Conclusions  Th1- and Th2-related cytokines in nasal secretions can serve as an objective criterion for evaluating therapeutic efficacy, which can be used in subsequent related studies.

     

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