Research progress on the mechanism of ferroptosis and its application in primary immune thrombocytopenia

Ferroptosis is an iron-dependently regulated form of programmed cell death driven by ironions and characterized by abnormal accumulation of lipid peroxidation products and failure of anti-oxidantdefense systems. In recent years,although significant progress has been made in the study of ferroptosis inoncology, neurodegenerative diseases and metabolic disorders, its role in hematologic diseases such as immune thrombocytopenia (ITP) has not yet been systematically elucidated.This paper provides a systematic review of the molecular mechanisms of ferroptosis and its potential links to the pathophysiology of ITP, offering a theoretical basis for elucidating new mechanisms of ITP pathogenesis and optimizing treatment strategies.