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LI Chenxi, SHEN Yang, ZHANG Xiaoling, LIU Yuchuan, LU Tao, YANG Yucheng. Developing an objective evaluation system based on cytokine profile in nasal secretions for allergic rhinitis treatment outcomes: a scoping reviewJ. Journal of New Medicine, 2026, 57(2): 184-195. DOI: 10.12464/j.issn.0253-9802.2025-0342
Citation: LI Chenxi, SHEN Yang, ZHANG Xiaoling, LIU Yuchuan, LU Tao, YANG Yucheng. Developing an objective evaluation system based on cytokine profile in nasal secretions for allergic rhinitis treatment outcomes: a scoping reviewJ. Journal of New Medicine, 2026, 57(2): 184-195. DOI: 10.12464/j.issn.0253-9802.2025-0342
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Developing an objective evaluation system based on cytokine profile in nasal secretions for allergic rhinitis treatment outcomes: a scoping review

    Abstract
  • Objective  To analyze the characteristics of cytokine profile changes in nasal secretions of allergic rhinitis (AR)patients receiving different treatments, with the aim of informing an objective, biomarker-based system for clinical efficacy assessment and guiding future research and policy development.
    Methods To explore objective evaluation indicators, this study conducted a comprehensive search of the studies related to cytokine detection and analysis of in nasal secretions in databases such as PubMed, Web of Science, CNKI and Wanfang Data, covering the period from July 1, 2015 to July 1, 2025.
    Results  118 studies met the inclusion criteria. Across multiple investigations, the levels of Th2-related cytokines consistently decreased after treatment, whereas those of Th1-related cytokines generally increased.
    Conclusions  Th1- and Th2-related cytokines in nasal secretions can serve as an objective criterion for evaluating therapeutic efficacy, which can be used in subsequent related studies.
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